MOSAIC : Development of a new pain-free psychotherapy for PTSD

This meeting, in the context of the 80th anniversary of D-Day, will bring together experts from around the world to present and discuss recent advances in our understanding and effective treatments of the mental health consequences of exposure to traumatic events such as war, interpersonal violence and natural disasters.

Conference in Caen, France

22-24 may 2024

"What is MOSAIC therapy, this therapy without suffering ??"

Webinar Conference

Information :

May 30, 2024


Scientific days of the ABC network of Psychotraumas

Paris – France

January 16 2024

From EMDR to MOSAIC therapy
Pain-free healing from psychological trauma

Rabat – Morocco

September 7 2023

Moving from a neurophysiological model to a therapeutic model in Post Traumatic Stress Disorder

Laboratoire de Neurosciences cognitives- Marseille

22 mai 2023

Effect of bilateral alternating stimulation on fear extinction

COEX – Seoul – Korea

1-4 june 2023

De l'EMDR à la thérapie MOSAIC, pour éviter l'exposition dans le PTSD complexe

Study Days 2023: Individuals in vulnerable situations and complex PTSD, Bordeaux

March 30-31, 2023

De l’EMDR à la thérapie MOSAIC : les mécanismes cérébraux

4th Annual International EMDR Congress Morocco

December 1-4, 2022

Experiencing your desired internal sensations with MOSAIC therapy

Masterclass Quantum Way

7th june 2022

MOSAIC therapy : painless healing of psychological trauma

Quantum Way

18-24 april 2022

Comment la thérapie EMDR peut-elle modifier la mémoire traumatique ?

XII Days of Psychiatry and Clinical Psychology, La Réunion

November 14-15, 2019

10 ans de recherche pour comprendre les mécanismes de l’EMDR

2nd French EMDR Congress, Metz

September 5-8, 2019

Prise en charge du traumatisme psychique par la thérapie EMDR et mécanismes cérébraux impliqués

Signoret Seminar, Caen

March 19-21, 2019

La mémoire traumatique et son évolution en thérapie EMDR

GDR Memory, Aix-en-Provence

16 May 2019


From EMDR to MOSAIC therapy

Painless healing of psychological trauma


  • Study in progress – Multicenter clinical trial on MOSAIC therapy. Project led by Pr Yann MIKAELOFF (APHP).
  • First observational clinical study of MOSAIC therapy in PTSD : Flatot-Blin D, Rey A, Derynck F, Fossard O, Khalfa S (2023). Clinical Efficiency and Acceptability of EMDR and MOSAIC Therapy for PTSD. Healthcare 11(15), 2226.
  • Khalfa S, Poupard G. MOSAIC: A New Pain-Free Psychotherapy for Psychological Trauma. Am J Psychother. 2021 Mar 1;74(1):40-43.

Scientific literature

  • Rousseau PF, Vallat R, Coste O, Cadis H, Nicolas F, Trousselard M, Ruby P, Khalfa S. Sleep parameters improvement in PTSD soldiers after symptoms remission. Scientific Reports 2021 ; 11(1) : 8873.
  • Rousseau PF, Boukezzi S, Garcia R, Chaminade T, Khalfa S. Cracking the EMDR code: Recruitment of sensory, memory and emotional networks during bilateral alternating auditory stimulation. Aust N Z J Psychiatry. 2020 Apr 9:4867420913623.
  • Khalfa S, Poupard G. MOSAIC: A New Pain-Free Psychotherapy for Psychological Trauma. Am J Psychother. 2021 Mar 1;74(1):40-43.
  • Verger A, Rousseau PF, Malbos E, Chawkia MB, Nicolas F, Lançon C, Khalfa S, Guedj E. Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD. European Journal of Psychotraumatology 2020, 11, 1767986.
  • Khalfa S. Prise en charge du traumatisme psychique par la thérapie EMDR et mécanismes cérébraux impliqués. Revue de Neuropsychologie 7. 2019.
  • Rousseau PF, Malbos E, Verger A, Nicolas F, Lançon C, Khalfa S, Guedj E. Increase of precuneus metabolism correlates with reduction of PTSD symptoms after EMDR therapy in military veterans: an 18F-FDG PET study during virtual reality exposure to war. European Journal of Nuclear Medicine and Molecular Imaging. 2019; 46(9): 1817-1821.
  • Rousseau P-F, El Khoury-Malhame M, Reynaud E, Boukezzi S, Cancel A, Zendjidjian X, Guyon V, Samuelian JC, Guedj E, Chaminade T, Khalfa S. Fear extinction learning improvement in PTSD after EMDR therapy: an fMRI study. Eur J Psychotrauma. 2019; 3(2): 103-111.
  • Rousseau PF, El Khoury-Malhame M, Reynaud E, Zendjidjian X, Samuelian JC, Khalfa S. Neurobiological correlates of EMDR therapy effect in PTSD. European Journal of Trauma and Dissociation. 2018; 3(2): 103-111.
  • Khalfa S & Touzet C. EMDR Therapy Mechanisms Explained by the Theory of Neural Cognition. Journal of Traumatic Stress Disorders & Treatment. 2017, 6:4.
  • Boukezzi S, El Khoury-Malhame M, Auzias G, Reynaud E, Rousseau PF, Richard E, Zendjidjian X, Roques J, Castelli N, Correard N, Guyon V, Gellato C, Samuelian JC, Cancel A, Comte M, Latinus M, Guedj E, Khalfa S. Grey matter density changes of structures involved in Posttraumatic Stress Disorder (PTSD) after recovery following Eye Movement Desensitization and Reprocessing (EMDR) therapy. Psychiatry Res. 2017 Aug 30; 266:146-152.
  • Boukezzi S, Silva C, Nazarian B, Rousseau PF, Guedj E, Valenzuela-Moguillansky C, Khalfa S. Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval. Front Psychol. 2017 Jun 14;8:990.
  • Wurtz H, El-Khoury-Malhame M, Wilhelm F, Michael T, Beetz EM, Roques J, Reynaud E, Courtin J, Khalfa S (co-last author), Herry C. Preventing long-lasting fear recovery using bilateral alternating sensory stimulation: a translational study. Neuroscience 2016; 321: 222-235.